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Identification of P-glycoprotein co-fractionating proteins and specific binding partners in rat brain microvessels

Drug delivery to the brain for the treatment of pathologies with a CNS component is a significant clinical challenge. P-glycoprotein (PgP), a drug efflux pump in the endothelial cell membrane, is a major factor in preventing therapeutics from crossing the blood-brain barrier (BBB). Identifying PgP r...

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Bibliografische gegevens
Gepubliceerd in:J Neurochem
Hoofdauteurs: Tome, Margaret E., Schaefer, Charles P., Jacobs, Leigh M., Zhang, Yifeng, Herndon, Joseph M., Matty, Fabian O., Davis, Thomas P.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490986/
https://ncbi.nlm.nih.gov/pubmed/25832806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.13106
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