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Exon 4-encoded sequence is a major determinant of cytotoxicity of apolipoprotein L1

The apolipoprotein L1 (APOL1) gene (APOL1) product is toxic to kidney cells, and its G1 and G2 alleles are strongly associated with increased risk for kidney disease progression in African Americans. Variable penetrance of the G1 and G2 risk alleles highlights the significance of additional factors...

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Detalhes bibliográficos
Publicado no:Am J Physiol Cell Physiol
Main Authors: Khatua, Atanu K., Cheatham, Amber M., Kruzel, Etty D., Singhal, Pravin C., Skorecki, Karl, Popik, Waldemar
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490327/
https://ncbi.nlm.nih.gov/pubmed/25924622
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00384.2014
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