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Exon 4-encoded sequence is a major determinant of cytotoxicity of apolipoprotein L1
The apolipoprotein L1 (APOL1) gene (APOL1) product is toxic to kidney cells, and its G1 and G2 alleles are strongly associated with increased risk for kidney disease progression in African Americans. Variable penetrance of the G1 and G2 risk alleles highlights the significance of additional factors...
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| Publié dans: | Am J Physiol Cell Physiol |
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| Auteurs principaux: | , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Physiological Society
2015
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4490327/ https://ncbi.nlm.nih.gov/pubmed/25924622 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00384.2014 |
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