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Blocking the 5′ splice site of exon 4 by a morpholino oligomer triggers APOL1 protein isoform switch
APOL1 risk alleles G1 or G2 are associated with a kidney disease phenotype exclusively in people of recent African ancestry. Here we show that exon 4 encoding a part of the APOL1 signal peptide is constitutively spliced in major APOL1 transcripts expressed in kidney glomerular and tubular cells. We...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5992166/ https://ncbi.nlm.nih.gov/pubmed/29880816 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-27104-x |
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