Phosphorodiamidate morpholino targeting the 5′ untranslated region of the ZIKV RNA inhibits virus replication

BACKGROUND: Zika virus (ZIKV) infection has been associated with microcephaly in infants. Currently there is no treatment or vaccine. Here we explore the use of a morpholino oligonucleotide targeted to the 5′ untranslated region (5′-UTR) of the ZIKV RNA to prevent ZIKV replication. METHODS: Morpholi...

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Bibliografiska uppgifter
I publikationen:Virology
Huvudupphovsmän: Popik, Waldemar, Khatua, Atanu, Hildreth, James E.K., Lee, Benjamin, Alcendor, Donald J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2018
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6503319/
https://ncbi.nlm.nih.gov/pubmed/29679791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2018.04.001
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