A decoy peptide that disrupts TIRAP recruitment to TLRs protects in a murine model of influenza

Toll-like receptors (TLRs) activate distinct, yet overlapping sets of signaling molecules, leading to inflammatory responses to pathogens. Toll-IL-1R (TIR) domains, present in all TLRs and TLR adapters, mediate protein interactions downstream of activated TLRs. A peptide library derived from TLR2 TI...

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Bibliografiske detaljer
Udgivet i:Cell Rep
Main Authors: Piao, Wenji, Shirey, Kari Ann, Ru, Lisa W., Lai, Wendy, Szmacinski, Henryk, Snyder, Greg A., Sundberg, Eric J., Lakowicz, Joseph R., Vogel, Stefanie N., Toshchakov, Vladimir Y.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490105/
https://ncbi.nlm.nih.gov/pubmed/26095366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.05.035
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