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Molecular mechanism of vinculin activation and nano-scale spatial organization in focal adhesions

Focal adhesions (FAs) link the extracellular matrix (ECM) to the actin cytoskeleton to mediate cell adhesion, migration, mechanosensing and signaling. FAs have conserved nanoscale protein organization, suggesting that the position of proteins within FAs regulates their activity and function. Vinculi...

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Detalles Bibliográficos
Publicado en:Nat Cell Biol
Main Authors: Case, Lindsay B., Baird, Michelle A., Shtengel, Gleb, Campbell, Sharon L., Hess, Harald F., Davidson, Michael W., Waterman, Clare M.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490039/
https://ncbi.nlm.nih.gov/pubmed/26053221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3180
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