Molecular mechanism of vinculin activation and nano-scale spatial organization in focal adhesions

Focal adhesions (FAs) link the extracellular matrix (ECM) to the actin cytoskeleton to mediate cell adhesion, migration, mechanosensing and signaling. FAs have conserved nanoscale protein organization, suggesting that the position of proteins within FAs regulates their activity and function. Vinculi...

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Udgivet i:Nat Cell Biol
Main Authors: Case, Lindsay B., Baird, Michelle A., Shtengel, Gleb, Campbell, Sharon L., Hess, Harald F., Davidson, Michael W., Waterman, Clare M.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490039/
https://ncbi.nlm.nih.gov/pubmed/26053221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb3180
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