Gene delivery to the spinal cord using MRI-guided focused ultrasound

Non-invasive gene delivery across the blood-spinal cord barrier (BSCB) remains a challenge for treatment of spinal cord injury or disease. Here, we demonstrate the use of magnetic resonance imaging-guided focused ultrasound (MRIgFUS) to mediate non-surgical gene delivery to the spinal cord, using se...

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Detalhes bibliográficos
Publicado no:Gene Ther
Main Authors: Weber-Adrian, Danielle, Thévenot, Emmanuel, O'Reilly, Meaghan A., Oakden, Wendy, Akens, Margarete K., Ellens, Nicholas, Markham-Coultes, Kelly, Burgess, Alison, Finkelstein, Joel, Yee, Albert J.M., Whyne, Cari M., Foust, Kevin D., Kaspar, Brian K., Stanisz, Greg J., Chopra, Rajiv, Hynynen, Kullervo, Aubert, Isabelle
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490035/
https://ncbi.nlm.nih.gov/pubmed/25781651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2015.25
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