microRNA-181a-5p Inhibits Cancer Cell Migration and Angiogenesis via Downregulation of Matrix Metalloproteinase-14

Upregulation of matrix metalloproteinase MMP-14 (MT1-MMP) is associated with poor prognosis in cancer patients, but it is unclear how MMP-14 becomes elevated in tumors. Here we show that miR-181a-5p is downregulated in aggressive human breast and colon cancers where its levels correlate inversely wi...

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Veröffentlicht in:Cancer Res
Hauptverfasser: Li, Yiyi, Kuscu, Cem, Banach, Anna, Zhang, Qian, Pulkoski-Gross, Ashleigh, Kim, Deborah, Liu, Jingxuan, Roth, Eric, Li, Ellen, Shroyer, Kenneth R, Denoya, Paula I, Zhu, Xiaoxia, Chen, Longhua, Cao, Jian
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4489986/
https://ncbi.nlm.nih.gov/pubmed/25977338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-2875
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