Dissecting the Mechanisms of Doxorubicin and Oxidative Stress-Induced Cytotoxicity: The Involvement of Actin Cytoskeleton and ROCK1

We have recently reported that ROCK1 deficiency in mouse embryonic fibroblasts (MEF) has superior anti-apoptotic and pro-survival effects than antioxidants against doxorubicin, a chemotherapeutic drug. Although oxidative stress is the most widely accepted mechanism, our studies suggest that ROCK1-de...

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Veröffentlicht in:PLoS One
Hauptverfasser: Wei, Lei, Surma, Michelle, Gough, Gina, Shi, Stephanie, Lambert-Cheatham, Nathan, Chang, Jiang, Shi, Jianjian
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4489912/
https://ncbi.nlm.nih.gov/pubmed/26134406
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131763
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