BRCA1 Regulates IFI16 Mediated Nuclear Innate Sensing of Herpes Viral DNA and Subsequent Induction of the Innate Inflammasome and Interferon-β Responses

The innate immune system pattern recognition receptors (PRR) are the first line of host defenses recognizing the various pathogen- or danger-associated molecular patterns and eliciting defenses by regulating the production of pro-inflammatory cytokines such as IL-1β, IL-18 or interferon β (IFN-β). N...

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Veröffentlicht in:PLoS Pathog
Hauptverfasser: Dutta, Dipanjan, Dutta, Sujoy, Veettil, Mohanan Valiya, Roy, Arunava, Ansari, Mairaj Ahmed, Iqbal, Jawed, Chikoti, Leela, Kumar, Binod, Johnson, Karen E., Chandran, Bala
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4487893/
https://ncbi.nlm.nih.gov/pubmed/26121674
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005030
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