Identification of a Dynamic Core Transcriptional Network in t(8;21) AML that Regulates Differentiation Block and Self-Renewal

Oncogenic transcription factors such as RUNX1/ETO, which is generated by the chromosomal translocation t(8;21), subvert normal blood cell development by impairing differentiation and driving malignant self-renewal. Here, we use digital footprinting and chromatin immunoprecipitation sequencing (ChIP-...

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Vydáno v:Cell Rep
Hlavní autoři: Ptasinska, Anetta, Assi, Salam A., Martinez-Soria, Natalia, Imperato, Maria Rosaria, Piper, Jason, Cauchy, Pierre, Pickin, Anna, James, Sally R., Hoogenkamp, Maarten, Williamson, Dan, Wu, Mengchu, Tenen, Daniel G., Ott, Sascha, Westhead, David R., Cockerill, Peter N., Heidenreich, Olaf, Bonifer, Constanze
Médium: Artigo
Jazyk:Inglês
Vydáno: Cell Press 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4487811/
https://ncbi.nlm.nih.gov/pubmed/25242324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.08.024
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