Stochastic modelling, Bayesian inference, and new in vivo measurements elucidate the debated mtDNA bottleneck mechanism

Dangerous damage to mitochondrial DNA (mtDNA) can be ameliorated during mammalian development through a highly debated mechanism called the mtDNA bottleneck. Uncertainty surrounding this process limits our ability to address inherited mtDNA diseases. We produce a new, physically motivated, generalis...

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Publicat a:eLife
Autors principals: Johnston, Iain G, Burgstaller, Joerg P, Havlicek, Vitezslav, Kolbe, Thomas, Rülicke, Thomas, Brem, Gottfried, Poulton, Jo, Jones, Nick S
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2015
Matèries:
Computational and Systems Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4486817/
https://ncbi.nlm.nih.gov/pubmed/26035426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.07464
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