Large-scale genetic analysis reveals mammalian mtDNA heteroplasmy dynamics and variance increase through lifetimes and generations

Vital mitochondrial DNA (mtDNA) populations exist in cells and may consist of heteroplasmic mixtures of mtDNA types. The evolution of these heteroplasmic populations through development, ageing, and generations is central to genetic diseases, but is poorly understood in mammals. Here we dissect thes...

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Udgivet i:Nat Commun
Main Authors: Burgstaller, Joerg P., Kolbe, Thomas, Havlicek, Vitezslav, Hembach, Stephanie, Poulton, Joanna, Piálek, Jaroslav, Steinborn, Ralf, Rülicke, Thomas, Brem, Gottfried, Jones, Nick S., Johnston, Iain G.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6021422/
https://ncbi.nlm.nih.gov/pubmed/29950599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-04797-2
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