MtDNA segregation in heteroplasmic tissues is common in vivo and modulated by haplotype differences and developmental stage

The dynamics by which mitochondrial DNA (mtDNA) evolves within organisms are still poorly understood, despite the fact that inheritance and proliferation of mutated mtDNA causes fatal and incurable diseases. When two mtDNA haplotypes are present in a cell, it is usually assumed that segregation (the...

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Publicado no:Cell Rep
Main Authors: Burgstaller, Joerg Patrick, Johnston, Iain G., Jones, Nick S., Albrechtová, Jana, Kolbe, Thomas, Vogl, Claus, Futschik, Andreas, Mayrhofer, Corina, Klein, Dieter, Sabitzer, Sonja, Blattner, Mirjam, Gülly, Christian, Poulton, Joanna, Rülicke, Thomas, Piálek, Jaroslav, Steinborn, Ralf, Brem, Gottfried
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4570183/
https://ncbi.nlm.nih.gov/pubmed/24910436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.05.020
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