MtDNA segregation in heteroplasmic tissues is common in vivo and modulated by haplotype differences and developmental stage

The dynamics by which mitochondrial DNA (mtDNA) evolves within organisms are still poorly understood, despite the fact that inheritance and proliferation of mutated mtDNA causes fatal and incurable diseases. When two mtDNA haplotypes are present in a cell, it is usually assumed that segregation (the...

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Bibliographic Details
Published in:Cell Rep
Main Authors: Burgstaller, Joerg Patrick, Johnston, Iain G., Jones, Nick S., Albrechtová, Jana, Kolbe, Thomas, Vogl, Claus, Futschik, Andreas, Mayrhofer, Corina, Klein, Dieter, Sabitzer, Sonja, Blattner, Mirjam, Gülly, Christian, Poulton, Joanna, Rülicke, Thomas, Piálek, Jaroslav, Steinborn, Ralf, Brem, Gottfried
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4570183/
https://ncbi.nlm.nih.gov/pubmed/24910436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.05.020
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