MtDNA segregation in heteroplasmic tissues is common in vivo and modulated by haplotype differences and developmental stage

The dynamics by which mitochondrial DNA (mtDNA) evolves within organisms are still poorly understood, despite the fact that inheritance and proliferation of mutated mtDNA causes fatal and incurable diseases. When two mtDNA haplotypes are present in a cell, it is usually assumed that segregation (the...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Cell Rep
Päätekijät: Burgstaller, Joerg Patrick, Johnston, Iain G., Jones, Nick S., Albrechtová, Jana, Kolbe, Thomas, Vogl, Claus, Futschik, Andreas, Mayrhofer, Corina, Klein, Dieter, Sabitzer, Sonja, Blattner, Mirjam, Gülly, Christian, Poulton, Joanna, Rülicke, Thomas, Piálek, Jaroslav, Steinborn, Ralf, Brem, Gottfried
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2014
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4570183/
https://ncbi.nlm.nih.gov/pubmed/24910436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.05.020
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