Immunomodulatory drugs target IKZF1-IRF4-MYC axis in primary effusion lymphoma in a cereblon-dependent manner and display synergistic cytotoxicity with BRD4 inhibitors

Primary effusion lymphoma (PEL) is an aggressive type of non-Hodgkin lymphoma localized predominantly in body cavities. Kaposi’s sarcoma-associated herpes virus is the causative agent of PEL. PEL is an incurable malignancy and has extremely poor prognosis when treated with conventional chemotherapy....

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Publicado en:Oncogene
Autores principales: Gopalakrishnan, Ramakrishnan, Matta, Hittu, Tolani, Bhairavi, Triche, Tim, Chaudhary, Preet M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4486341/
https://ncbi.nlm.nih.gov/pubmed/26119939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.245
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