Kaposi’s Sarcoma Associated Herpesvirus Encoded Viral FLICE Inhibitory Protein K13 Activates NF-κB Pathway Independent of TRAF6, TAK1 and LUBAC

BACKGROUND: Kaposi’s sarcoma associated herpesvirus encoded viral FLICE inhibitory protein (vFLIP) K13 activates the NF-κB pathway by binding to the NEMO/IKKγ subunit of the IκB kinase (IKK) complex. However, it has remained enigmatic how K13-NEMO interaction results in the activation of the IKK com...

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Detalhes bibliográficos
Main Authors: Matta, Hittu, Gopalakrishnan, Ramakrishnan, Graham, Ciaren, Tolani, Bhairavi, Khanna, Akshat, Yi, Han, Suo, Yulan, Chaudhary, Preet M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3348130/
https://ncbi.nlm.nih.gov/pubmed/22590573
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036601
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