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A purine scaffold HSP90 inhibitor BIIB021 has selective activity against KSHV-associated Primary Effusion Lymphoma and blocks vFLIP K13-induced NF-κB
PURPOSE: Kaposi's sarcoma associated herpesvirus (KSHV) associated primary effusion lymphomas (PEL) have extremely poor prognosis when treated with conventional chemotherapy. KSHV-encoded viral FLICE Inhibitory Protein (vFLIP) K13 binds to the IkappaB Kinase (IKK) complex to constitutively acti...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3804723/ https://ncbi.nlm.nih.gov/pubmed/23881928 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-12-3510 |
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