LKB1 deficiency enhances sensitivity to energetic stress induced by erlotinib treatment in non-small cell lung cancer (NSCLC) cells

The tumor suppressor serine/threonine kinase 11 (STK11 or LKB1) is mutated in 20–30% of non-small cell lung cancer (NSCLC) patient tumors. Loss of LKB1-AMPK signaling confers sensitivity to metabolic inhibition or stress-induced mitochondrial insults. We tested the hypothesis that loss of LKB1 sensi...

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Pubblicato in:Oncogene
Autori principali: Whang, Young Mi, Park, Serk In, Trenary, Irina A., Egnatchik, Robert A., Fessel, Joshua P., Kaufman, Jacob M., Carbone, David P., Young, Jamey D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4486321/
https://ncbi.nlm.nih.gov/pubmed/26119936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2015.140
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