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LKB1 and AMPK maintain epithelial cell polarity under energetic stress

LKB1 is mutated in both familial and spontaneous tumors, and acts as a master kinase that activates the PAR-1 polarity kinase and the adenosine 5′monophosphate–activated kinase (AMPK). This has led to the hypothesis that LKB1 acts as a tumor suppressor because it is required to maintain cell polarit...

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Detalhes bibliográficos
Main Authors: Mirouse, Vincent, Swick, Lance L., Kazgan, Nevzat, St Johnston, Daniel, Brenman, Jay E.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064817/
https://ncbi.nlm.nih.gov/pubmed/17470638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200702053
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