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LKB1 and AMPK maintain epithelial cell polarity under energetic stress
LKB1 is mutated in both familial and spontaneous tumors, and acts as a master kinase that activates the PAR-1 polarity kinase and the adenosine 5′monophosphate–activated kinase (AMPK). This has led to the hypothesis that LKB1 acts as a tumor suppressor because it is required to maintain cell polarit...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Rockefeller University Press
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2064817/ https://ncbi.nlm.nih.gov/pubmed/17470638 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200702053 |
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