Heightening energetic stress selectively targets LKB1-deficient non-small cell lung cancers

Inactivation of the LKB1 tumor suppressor is a frequent event in non-small cell lung carcinoma (NSCLC) leading to the activation of mammalian target of rapamycin complex 1 (mTORC1) and sensitivity to the metabolic stress inducer phenformin. In this study, we explored the combinatorial use of phenfor...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Momcilovic, Milica, McMickle, Robert, Abt, Evan, Seki, Atsuko, Simko, Sarah A., Magyar, Clara, Stout, David B., Fishbein, Michael C., Walser, Tonya C., Dubinett, Steven M., Shackelford, David B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4654699/
https://ncbi.nlm.nih.gov/pubmed/26574479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-0797
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