Altered Interactions between the Gut Microbiome and Colonic Mucosa Precede Polyposis in APC(Min/+) Mice

Mutation of the adenomatous polyposis coli (APC gene), an early event in the adenoma-carcinoma sequence, is present in 70-80% of sporadic human colorectal adenomas and carcinomas. To test the hypothesis that mutation of the APC gene alters microbial interactions with host intestinal mucosa prior to...

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Bibliographic Details
Published in:PLoS One
Main Authors: Son, Joshua S., Khair, Shanawaj, Pettet, Donald W., Ouyang, Nengtai, Tian, Xinyu, Zhang, Yuanhao, Zhu, Wei, Mackenzie, Gerardo G., Robertson, Charles E., Ir, Diana, Frank, Daniel N., Rigas, Basil, Li, Ellen
Format: Artigo
Language:Inglês
Published: Public Library of Science 2015
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485894/
https://ncbi.nlm.nih.gov/pubmed/26121046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0127985
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