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Structural Basis for the Specificity of Human NUDT16 and Its Regulation by Inosine Monophosphate

Human NUDT16 is a member of the NUDIX hydrolase superfamily. After having been initially described as an mRNA decapping enzyme, recent studies conferred it a role as an “housecleaning” enzyme specialized in the removal of hazardous (deoxy)inosine diphosphate from the nucleotide pool. Here we present...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Trésaugues, Lionel, Lundbäck, Thomas, Welin, Martin, Flodin, Susanne, Nyman, Tomas, Silvander, Camilla, Gräslund, Susanne, Nordlund, Pär
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485890/
https://ncbi.nlm.nih.gov/pubmed/26121039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0131507
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