Structural studies of tri-functional human GART

Human purine de novo synthesis pathway contains several multi-functional enzymes, one of which, tri-functional GART, contains three enzymatic activities in a single polypeptide chain. We have solved structures of two domains bearing separate catalytic functions: glycinamide ribonucleotide synthetase...

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Main Authors: Welin, Martin, Grossmann, Jörg Günter, Flodin, Susanne, Nyman, Tomas, Stenmark, Pål, Trésaugues, Lionel, Kotenyova, Tetyana, Johansson, Ida, Nordlund, Pär, Lehtiö, Lari
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2010
Teme:
Structural Biology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978367/
https://ncbi.nlm.nih.gov/pubmed/20631005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq595
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