Implications of understanding the signaling, cellular, and cytotoxic mechanisms afforded by afucosylated antibodies

Afucosylated antibodies potentiate natural killer (NK) cell-mediated antibody-dependent cellular cytotoxicity (ADCC) by enhancing signaling pathways and cellular processes, which in turn, increases cytotoxic potential. Importantly, a better understanding of these processes and properties will aid in...

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Veröffentlicht in:Oncoimmunology
Hauptverfasser: Liu, Scot D, Lowe, John B
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2015
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485832/
https://ncbi.nlm.nih.gov/pubmed/26155429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/2162402X.2015.1009288
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