Liver myeloid-derived suppressor cells expand in response to liver metastases in mice and inhibit the anti-tumor efficacy of anti-CEA CAR-T

Chimeric antigen receptor-modified T cell (CAR-T) technology, a promising immunotherapeutic tool, has not been applied specifically to treat liver metastases (LM). While CAR-T delivery to LM can be optimized by regional intrahepatic infusion, we propose that liver CD11b+Gr-1+ myeloid-derived suppres...

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Detalhes bibliográficos
Publicado no:Cancer Immunol Immunother
Main Authors: Burga, Rachel A., Thorn, Mitchell, Point, Gary R., Guha, Prajna, Nguyen, Cang T., Licata, Lauren A., DeMatteo, Ronald P., Ayala, Alfred, Joseph Espat, N., Junghans, Richard P., Katz, Steven C.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485571/
https://ncbi.nlm.nih.gov/pubmed/25850344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-015-1692-6
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