Frontline Science: Functionally impaired geriatric CAR‐T cells rescued by increased α5β1 integrin expression

Chimeric antigen receptor expressing T cells (CAR‐T) are a promising form of immunotherapy, but the influence of age‐related immune changes on CAR‐T production remains poorly understood. We showed that CAR‐T cells from geriatric donors (gCAR‐T) are functionally impaired relative to CAR‐T from younge...

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Bibliografiske detaljer
Udgivet i:J Leukoc Biol
Main Authors: Guha, Prajna, Cunetta, Marissa, Somasundar, Ponnandai, Espat, N. Joseph, Junghans, Richard P., Katz, Steven C.
Format: Artigo
Sprog:Inglês
Udgivet: John Wiley and Sons Inc. 2017
Fag:
Spotlight on Leading Edge Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6608072/
https://ncbi.nlm.nih.gov/pubmed/28546503
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.5HI0716-322RR
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