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Frontline Science: Functionally impaired geriatric CAR‐T cells rescued by increased α5β1 integrin expression
Chimeric antigen receptor expressing T cells (CAR‐T) are a promising form of immunotherapy, but the influence of age‐related immune changes on CAR‐T production remains poorly understood. We showed that CAR‐T cells from geriatric donors (gCAR‐T) are functionally impaired relative to CAR‐T from younge...
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| Udgivet i: | J Leukoc Biol |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
John Wiley and Sons Inc.
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6608072/ https://ncbi.nlm.nih.gov/pubmed/28546503 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1189/jlb.5HI0716-322RR |
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