Reduction of Neuropathic and Inflammatory Pain through Inhibition of the Tetrahydrobiopterin Pathway

Human genetic studies have revealed an association between GTP cyclohydrolase 1 polymorphisms, which decrease tetrahydrobiopterin (BH4) levels, and reduced pain in patients. We now show that excessive BH4 is produced in mice by both axotomized sensory neurons and macrophages infiltrating damaged ner...

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Bibliografiset tiedot
Julkaisussa:Neuron
Päätekijät: Latremoliere, Alban, Latini, Alexandra, Andrews, Nick, Cronin, Shane J., Fujita, Masahide, Gorska, Katarzyna, Hovius, Ruud, Romero, Carla, Chuaiphichai, Surawee, Painter, Michio, Miracca, Giulia, Babaniyi, Olusegun, Remor, Aline Pertile, Duong, Kelly, Riva, Priscilla, Barrett, Lee B., Ferreirós, Nerea, Naylor, Alasdair, Penninger, Josef M., Tegeder, Irmgard, Zhong, Jian, Blagg, Julian, Channon, Keith M., Johnsson, Kai, Costigan, Michael, Woolf, Clifford J.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2015
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485422/
https://ncbi.nlm.nih.gov/pubmed/26087165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2015.05.033
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