Disregulated expression of the transcription factor ThPOK during T-cell development leads to high incidence of T-cell lymphomas

The transcription factor T-helper-inducing POZ/Krueppel-like factor (ThPOK, encoded by the Zbtb7b gene) plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. Here we show that mice expressing a constitutive T-cell–specific ThPOK transgene...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Lee, Hyung-Ok, He, Xiao, Mookerjee-Basu, Jayati, Zhongping, Dai, Hua, Xiang, Nicolas, Emmanuelle, Sulis, Maria Luisa, Ferrando, Adolfo A., Testa, Joseph R., Kappes, Dietmar J.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2015
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485124/
https://ncbi.nlm.nih.gov/pubmed/26056302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1424104112
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