Impaired mitochondrial fat oxidation induces adaptive remodeling of muscle metabolism

The correlations between intramyocellular lipid (IMCL), decreased fatty acid oxidation (FAO), and insulin resistance have led to the hypothesis that impaired FAO causes accumulation of lipotoxic intermediates that inhibit muscle insulin signaling. Using a skeletal muscle-specific carnitine palmitoyl...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Wicks, Shawna E., Vandanmagsar, Bolormaa, Haynie, Kimberly R., Fuller, Scott E., Warfel, Jaycob D., Stephens, Jacqueline M., Wang, Miao, Han, Xianlin, Zhang, Jingying, Noland, Robert C., Mynatt, Randall L.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2015
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PNAS Plus
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4485116/
https://ncbi.nlm.nih.gov/pubmed/26056297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1418560112
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