FOXO1/3 and PTEN Depletion in Granulosa Cells Promotes Ovarian Granulosa Cell Tumor Development

The forkhead box (FOX), FOXO1 and FOXO3, transcription factors regulate multiple functions in mammalian cells. Selective inactivation of the Foxo1 and Foxo3 genes in murine ovarian granulosa cells severely impairs follicular development and apoptosis causing infertility, and as shown here, granulosa...

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Bibliographic Details
Published in:Mol Endocrinol
Main Authors: Liu, Zhilin, Ren, Yi A., Pangas, Stephanie A., Adams, Jaye, Zhou, Wei, Castrillon, Diego H., Wilhelm, Dagmar, Richards, JoAnne S.
Format: Artigo
Language:Inglês
Published: Endocrine Society 2015
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Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4484779/
https://ncbi.nlm.nih.gov/pubmed/26061565
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2015-1103
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