Cell Type-Specific Targeted Mutations of Kras and Pten Document Proliferation Arrest in Granulosa Cells Versus Oncogenic Insult to Ovarian Surface Epithelial Cells

The small G-protein KRAS is crucial for mediating gonadotropin-induced events associated with ovulation. However, constitutive expression of Kras(G12D) in granulosa cells disrupted normal follicle development leading to the persistence of abnormal follicle-like structures containing non-mitotic cell...

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Bibliografiset tiedot
Päätekijät: Fan, Heng-Yu, Liu, Zhilin, Paquet, Marilene, Wang, Jinrong, Lydon, John P., DeMayo, Francesco J., Richards, JoAnne S.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2009
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2741085/
https://ncbi.nlm.nih.gov/pubmed/19679546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-3363
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