Synergistic effects of Pten loss and WNT/CTNNB1 signaling pathway activation in ovarian granulosa cell tumor development and progression

The mechanisms of granulosa cell tumor (GCT) development may involve the dysregulation of signaling pathways downstream of follicle-stimulating hormone, including the phosphoinosite-3 kinase (PI3K)/AKT pathway. To test this hypothesis, a genetically engineered mouse model was created to derepress th...

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Bibliografiske detaljer
Main Authors: Laguë, Marie-Noëlle, Paquet, Marilène, Fan, Heng-Yu, Kaartinen, M. Johanna, Chu, Simon, Jamin, Soazik P., Behringer, Richard R., Fuller, Peter J., Mitchell, Andrew, Doré, Monique, Huneault, Louis M., Richards, JoAnne S., Boerboom, Derek
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2008
Fag:
Cancer Biology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2577137/
https://ncbi.nlm.nih.gov/pubmed/18687666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/carcin/bgn186
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