Calnexin induces expansion of antigen-specific CD4(+) T cells that confer immunity to fungal ascomycetes via conserved epitopes

Fungal infections remain a threat due to the lack of broad spectrum fungal vaccines and protective antigens. Recent studies showed that attenuated Blastomyces dermatitidis confers protection via T cell recognition of an unknown, but conserved antigen. Using transgenic CD4+ T cells recognizing this a...

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Detalhes bibliográficos
Publicado no:Cell Host Microbe
Main Authors: Wüthrich, Marcel, Brandhorst, Tristan T., Sullivan, Thomas D., Filutowicz, Hanna, Sterkel, Alana, Stewart, Douglas, Li, Mengyi, Lerksuthirat, Tassanee, LeBert, Vanessa, Shen, Zu Ting, Ostroff, Gary, Deepe, George S., Hung, Chiung Yu, Cole, Garry, Walter, Jennifer A., Jenkins, Marc K., Klein, Bruce
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4484745/
https://ncbi.nlm.nih.gov/pubmed/25800545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2015.02.009
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