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Improving dissolution and oral bioavailability of pranlukast hemihydrate by particle surface modification with surfactants and homogenization

The present study was carried out to develop an oral formulation of pranlukast hemihydrate with improved dissolution and oral bioavailability using a surface-modified microparticle. Based on solubility measurements, surface-modified pranlukast hemihydrate microparticles were manufactured using the s...

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Bibliographische Detailangaben
Veröffentlicht in:Drug Des Devel Ther
Hauptverfasser: Ha, Eun-Sol, Baek, In-hwan, Yoo, Jin-Wook, Jung, Yunjin, Kim, Min-Soo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Dove Medical Press 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4484661/
https://ncbi.nlm.nih.gov/pubmed/26150699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S87738
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