Development of megestrol acetate solid dispersion nanoparticles for enhanced oral delivery by using a supercritical antisolvent process

In the present study, solid dispersion nanoparticles with a hydrophilic polymer and surfactant were developed using the supercritical antisolvent (SAS) process to improve the dissolution and oral absorption of megestrol acetate. The physicochemical properties of the megestrol acetate solid dispersio...

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Vydáno v:Drug Des Devel Ther
Hlavní autoři: Ha, Eun-Sol, Kim, Jeong-Soo, Baek, In-hwan, Yoo, Jin-Wook, Jung, Yunjin, Moon, Hyung Ryong, Kim, Min-Soo
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove Medical Press 2015
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4531043/
https://ncbi.nlm.nih.gov/pubmed/26345723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S90706
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