FoxM1 promotes breast tumorigenesis by activating PDGF-A and forming a positive feedback loop with the PDGF/AKT signaling pathway

The autocrine platelet-derived growth factor (PDGF)/PDGF receptor (PDGFR) signaling pathway promotes breast cancer tumorigenesis, but the mechanisms for its dysregulation in breast cancer are largely unknown. In the study, we identified PDGF-A as a novel transcriptional target of FoxM1. FoxM1 direct...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Yu, Guanzhen, Zhou, Aidong, Xue, Jianfei, Huang, Chen, Zhang, Xia, Kang, Shin-Hyuk, Chiu, Wen-Tai, Tan, Christina, Xie, Keping, Wang, Jiejun, Huang, Suyun
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4484456/
https://ncbi.nlm.nih.gov/pubmed/25869208
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