Rab8a vesicles regulate Wnt ligand delivery and Paneth cell maturation at the intestinal stem cell niche

Communication between stem and niche supporting cells maintains the homeostasis of adult tissues. Wnt signaling is a crucial regulator of the stem cell niche, but the mechanism that governs Wnt ligand delivery in this compartment has not been fully investigated. We identified that Wnt secretion is p...

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Vydáno v:Development
Hlavní autoři: Das, Soumyashree, Yu, Shiyan, Sakamori, Ryotaro, Vedula, Pavan, Feng, Qiang, Flores, Juan, Hoffman, Andrew, Fu, Jiang, Stypulkowski, Ewa, Rodriguez, Alexis, Dobrowolski, Radek, Harada, Akihiro, Hsu, Wei, Bonder, Edward M., Verzi, Michael P., Gao, Nan
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists 2015
Témata:
Stem Cells and Regeneration
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4483769/
https://ncbi.nlm.nih.gov/pubmed/26015543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.121046
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