Brachyury and SMAD signalling collaboratively orchestrate distinct mesoderm and endoderm gene regulatory networks in differentiating human embryonic stem cells

The transcription factor brachyury (T, BRA) is one of the first markers of gastrulation and lineage specification in vertebrates. Despite its wide use and importance in stem cell and developmental biology, its functional genomic targets in human cells are largely unknown. Here, we use differentiatin...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Development
Autori principali: Faial, Tiago, Bernardo, Andreia S., Mendjan, Sasha, Diamanti, Evangelia, Ortmann, Daniel, Gentsch, George E., Mascetti, Victoria L., Trotter, Matthew W. B., Smith, James C., Pedersen, Roger A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Company of Biologists 2015
Soggetti:
Stem Cells and Regeneration
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4483767/
https://ncbi.nlm.nih.gov/pubmed/26015544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.117838
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