Brachyury and SMAD signalling collaboratively orchestrate distinct mesoderm and endoderm gene regulatory networks in differentiating human embryonic stem cells

The transcription factor brachyury (T, BRA) is one of the first markers of gastrulation and lineage specification in vertebrates. Despite its wide use and importance in stem cell and developmental biology, its functional genomic targets in human cells are largely unknown. Here, we use differentiatin...

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Enregistré dans:
Détails bibliographiques
Publié dans:Development
Auteurs principaux: Faial, Tiago, Bernardo, Andreia S., Mendjan, Sasha, Diamanti, Evangelia, Ortmann, Daniel, Gentsch, George E., Mascetti, Victoria L., Trotter, Matthew W. B., Smith, James C., Pedersen, Roger A.
Format: Artigo
Langue:Inglês
Publié: The Company of Biologists 2015
Sujets:
Stem Cells and Regeneration
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4483767/
https://ncbi.nlm.nih.gov/pubmed/26015544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.117838
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