BRACHYURY and CDX2 Mediate BMP-Induced Differentiation of Human and Mouse Pluripotent Stem Cells into Embryonic and Extraembryonic Lineages

BMP is thought to induce hESC differentiation toward multiple lineages including mesoderm and trophoblast. The BMP-induced trophoblast phenotype is a long-standing paradox in stem cell biology. Here we readdressed BMP function in hESCs and mouse epiblast-derived cells. We found that BMP4 cooperates...

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Detalhes bibliográficos
Main Authors: Bernardo, Andreia S., Faial, Tiago, Gardner, Lucy, Niakan, Kathy K., Ortmann, Daniel, Senner, Claire E., Callery, Elizabeth M., Trotter, Matthew W., Hemberger, Myriam, Smith, James C., Bardwell, Lee, Moffett, Ashley, Pedersen, Roger A.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3567433/
https://ncbi.nlm.nih.gov/pubmed/21816365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2011.06.015
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