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Dnmt1 is essential to maintain progenitors in the perinatal intestinal epithelium

The DNA methyltransferase Dnmt1 maintains DNA methylation patterns and genomic stability in several in vitro cell systems. Ablation of Dnmt1 in mouse embryos causes death at the post-gastrulation stage; however, the functions of Dnmt1 and DNA methylation in organogenesis remain unclear. Here, we rep...

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Detalles Bibliográficos
Publicado en:Development
Main Authors: Elliott, Ellen N., Sheaffer, Karyn L., Schug, Jonathan, Stappenbeck, Thaddeus S., Kaestner, Klaus H.
Formato: Artigo
Idioma:Inglês
Publicado: The Company of Biologists 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4483766/
https://ncbi.nlm.nih.gov/pubmed/26023099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.117341
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