Dnmt1 is essential to maintain progenitors in the perinatal intestinal epithelium

The DNA methyltransferase Dnmt1 maintains DNA methylation patterns and genomic stability in several in vitro cell systems. Ablation of Dnmt1 in mouse embryos causes death at the post-gastrulation stage; however, the functions of Dnmt1 and DNA methylation in organogenesis remain unclear. Here, we rep...

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Bibliographic Details
Published in:Development
Main Authors: Elliott, Ellen N., Sheaffer, Karyn L., Schug, Jonathan, Stappenbeck, Thaddeus S., Kaestner, Klaus H.
Format: Artigo
Language:Inglês
Published: The Company of Biologists 2015
Subjects:
Stem Cells and Regeneration
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4483766/
https://ncbi.nlm.nih.gov/pubmed/26023099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.117341
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