Phase II study of panobinostat in combination with bevacizumab for recurrent glioblastoma and anaplastic glioma

BACKGROUND: Panobinostat is a histone deacetylase inhibitor with antineoplastic and antiangiogenic effects in glioma that may work synergistically with bevacizumab. We conducted a multicenter phase II trial of panobinostat combined with bevacizumab in patients with recurrent high-grade glioma (HGG)....

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Lee, Eudocia Q., Reardon, David A., Schiff, David, Drappatz, Jan, Muzikansky, Alona, Grimm, Sean A., Norden, Andrew D., Nayak, Lakshmi, Beroukhim, Rameen, Rinne, Mikael L., Chi, Andrew S., Batchelor, Tracy T., Hempfling, Kelly, McCluskey, Christine, Smith, Katrina H., Gaffey, Sarah C., Wrigley, Brendan, Ligon, Keith L., Raizer, Jeffrey J., Wen, Patrick Y.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Clinical Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4483124/
https://ncbi.nlm.nih.gov/pubmed/25572329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou350
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