AT-36 PANOBINOSTAT IN COMBINATION WITH BEVACIZUMAB FOR RECURRENT GLIOBLASTOMA AND ANAPLASTIC GLIOMA

Bevacizumab is frequently used to treat recurrent high-grade gliomas, but responses are generally not durable. Panobinostat is a histone deacetylase inhibitor with anti-neoplastic and anti-angiogenic effects in glioma models and may work synergistically with bevacizumab. We conducted a multicenter p...

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Auteurs principaux: Lee, Eudocia, Reardon, David, Schiff, David, Drappatz, Jan, Muzikansky, Alona, Grimm, Sean, Norden, Andrew, Nayak, Lakshmi, Beroukhim, Rameen, Rinne, Mikael, Chi, Andrew, Batchelor, Tracy, Hempfling, Kelly, McCluskey, Christine, Smith, Katrina, Gaffey, Sarah, Wrigley, Brendan, Ligon, Keith, Raizer, Jeffrey, Wen, Patrick
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2014
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4217815/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou237.36
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