SIRT1 is required for oncogenic transformation of neural stem cells and for the survival of “cancer cells with neural stemness” in a p53-dependent manner

BACKGROUND: Cancer stemness, observed in several types of glioma stem cells (GSCs), has been demonstrated to be an important barrier for efficient cancer therapy. We have previously reported that cancerous neural stem cells (F3.Ras.CNSCs), derived from immortalized human neural stem cells by a singl...

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Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Lee, Ji-Seon, Park, Jeong-Rak, Kwon, Ok-Seon, Lee, Tae-Hee, Nakano, Ichiro, Miyoshi, Hiroyuki, Chun, Kwang-Hoon, Park, Myung-Jin, Lee, Hong Jun, Kim, Seung U., Cha, Hyuk-Jin
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2015
Fag:
Basic and Translational Investigations
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4483050/
https://ncbi.nlm.nih.gov/pubmed/25096191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou145
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