SIRT1 is required for oncogenic transformation of neural stem cells and for the survival of “cancer cells with neural stemness” in a p53-dependent manner

BACKGROUND: Cancer stemness, observed in several types of glioma stem cells (GSCs), has been demonstrated to be an important barrier for efficient cancer therapy. We have previously reported that cancerous neural stem cells (F3.Ras.CNSCs), derived from immortalized human neural stem cells by a singl...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Lee, Ji-Seon, Park, Jeong-Rak, Kwon, Ok-Seon, Lee, Tae-Hee, Nakano, Ichiro, Miyoshi, Hiroyuki, Chun, Kwang-Hoon, Park, Myung-Jin, Lee, Hong Jun, Kim, Seung U., Cha, Hyuk-Jin
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Basic and Translational Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4483050/
https://ncbi.nlm.nih.gov/pubmed/25096191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou145
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