Local delivery of cancer-cell glycolytic inhibitors in high-grade glioma

BACKGROUND: 3-bromopyruvate (3-BrPA) and dichloroacetate (DCA) are inhibitors of cancer-cell specific aerobic glycolysis. Their application in glioma is limited by 3-BrPA's inability to cross the blood-brain-barrier and DCA's dose-limiting toxicity. The safety and efficacy of intracranial...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Neuro Oncol
Autori principali: Wicks, Robert T., Azadi, Javad, Mangraviti, Antonella, Zhang, Irma, Hwang, Lee, Joshi, Avadhut, Bow, Hansen, Hutt-Cabezas, Marianne, Martin, Kristin L., Rudek, Michelle A., Zhao, Ming, Brem, Henry, Tyler, Betty M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2015
Soggetti:
Basic and Translational Investigations
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4483048/
https://ncbi.nlm.nih.gov/pubmed/25053853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou143
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