PDGFRα signaling in the primary cilium regulates NHE1-dependent fibroblast migration via coordinated differential activity of MEK1/2–ERK1/2–p90(RSK) and AKT signaling pathways

In fibroblasts, platelet-derived growth factor receptor alpha (PDGFRα) is upregulated during growth arrest and compartmentalized to the primary cilium. PDGF-AA mediated activation of the dimerized ciliary receptor produces a phosphorylation cascade through the PI3K–AKT and MEK1/2–ERK1/2 pathways lea...

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Detalhes bibliográficos
Publicado no:J Cell Sci
Main Authors: Clement, Ditte L., Mally, Sabine, Stock, Christian, Lethan, Mette, Satir, Peter, Schwab, Albrecht, Pedersen, Stine F., Christensen, Søren T.
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4481637/
https://ncbi.nlm.nih.gov/pubmed/23264740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.116426
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